While chemotherapy kills the most common type of bladder cancer, urothelial cancer, it also shapes the genetic evolution of remaining urothelial cancer cell clones to become drug-resistant, according to Bishoy Faltas and colleagues. Read more
David Rickman, Ph.D., and colleagues have identified a gene that appears to regulate the change from prostate adenocarcinoma to neuroendocrine prostate cancer. Read more
Alisertib monotherapy may be effective in certain patients with clinical or pathologically defined neuroendocrine prostate cancer, according to Himisha Beltran, M.D. Read more
A new collaboration will be formed to help further data analysis for the Cancer Genome Atlas project, thanks to a $490,000 grant from the National Cancer Institute. Read more
A community has rallied around an 8-year-old with pediatric brain cancer, and the doctor who has saved her life so far with his experimental treatment. Read more
A deep-freezing technique known as cryoablation is a viable alternative to traditional surgery in many early-stage breast cancers, according to Rache Simmons, M.D. Read more
Immuno-oncology and the classification of subtypes of gastric cancer could greatly advance treatment efficacy and variation, according to Manish A. Shah, M.D. Read more
Researchers from the lab of Olivier Elemento, Ph.D., have developed a promising new AI tool that better predicts which drug candidates are likely to be too toxic. Read more
The immunotherapy Tecentriq (atezolizumab) has been found to be non-toxic and has demonstrated a major survival advantage in patients with metastatic urothelial bladder cancer, according to David Nanus, M.D. Read more
Ari Melnick, M.D., has uncovered the mechanisms by which B-cells can transform to cause cancer, and found that it requires a special cooperation between regulatory protein EZH2 and transcription protein BCL6. Read more