The difference in treatment of left- and right-sided tumors in CRC
Tuesday, May 2, 2017
Manish A. Shah, M.D., spoke to OncLive about the difference in treatment of left- and right-sided tumors in colorectal cancer (CRC). Tumors are treated differently on the left and right side principally because the prevalence of biomarkers are different, says Shah. Left-sided tumors tend to be more sensitive to EGFR antibody inhibitors like cetuximab (Erbitux) or panitumumab. Right-sided colon cancers tend to be BRAF-driven, says Shah, so they are less sensitive to EGFR antibody inhibitors.