Sandra and Edward Meyer Cancer Center

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Molecular Mutations in MDS

Saturday, May 2, 2015

Gail J. Roboz, M.D., associate professor of medicine and director of Weill Cornell's Leukemia Program, discusses the growing field of molecular mutations in myelodysplastic syndromes (MDS) in this OncLive video.

Roboz says using molecular mutations for treatment and diagnosis of MDS received a lot of attention at the 2015 International MDS Symposium, which took place in Washington, D.C. on April 29-May 2. With new mutations coming out almost daily, it is difficult to know which mutations are commercially available to test and what to do with them, Roboz says.

Given that clonal hematopoiesis is common in older patients, it’s difficult to take some mutations identified in the panel and label a patient with an MDS diagnosis, Roboz says.

It is known that certain prognostic implications are given to certain molecular mutations, such as TET2, but since there is more than one mutation in patients, Roboz says it’s becoming harder to figure out how a whole series of mutational abnormalities might effect the prognosis of the patient, and how those might change with treatments.