Calendar

"Dissecting the Embryo with Single-cell RNA-Seq" Host: Joao Xavier Speaker: Itai Yanai, Ph.D. Director, Institute for Computational Medicine; Professor, Biochemistry and Molecular Pharmacology New York University School of Medicine, New York, NY Tea Time at 10:15 AM

Drs. Blenis and Guzman invite you to the revamped Biomedical Science Reviews Seminar Series BSRSS is intended to provide the most up-to-date reviews of translational biomedical research by leaders in their fields and talented new investigators, for faculty, lab researchers, and clinical fellows. The revamped series will be held at the Belfer Research Building and at the Weill Medical College. 10/28: Selina Chen-Kiang, PhD Targeting CDK4/6 in Cancer: From Hypothesis to Therapy

"Functions of BRCA1, BRCA2, and RAD51 Paralogs in Maintaining Chromosome Integrity" Stephen Kowalczykowski, Ph.D. Distinguished Professor of Microbiology & Molecular Genetics Distinguished Professor of Molecular & Cellular Biology University of California, Davis, Davis, CA Host: John Petrini Tea Time: 11:45 a.m.

Erika Hissong, M.D. Chief Pathology Resident "The Changing Face of Pathology: The Rise of Digital Pathology and the Social Pathologist" Luke Olson, M.D. Pathology Resident "Cell Phones and Cancer Risk: Is Your Addiction Killing You?" Monday, June 12, 2017 5p.m. John T. Ellis Pathology Library C-405

Host: Barry Sleckman (Cornell) Tea at 1:15 PM Location: RRL Auditorium Seminar Title: Gene Expression in Human Lymphoid Cells: Regulation in Two and Three Dimensions Name of Speaker: Eugene Oltz, Ph.D., Professor of Pathology & Immunology Director, Immunology Graduate Program Speaker's Affiliation: Washington University School of Medicine, St. Louis, MO

"Understanding the Diverging Disease Phenotypes of JAK2 V617F Mutations in Myeloproliferative Neoplasms via Single Cell Sequencing" Seung Anna Nam, M.D. Hematopathology Fellow "Tumor Immune Microenvironment in Hepatocellular Carcinoma" Dongmei Xing, M.D., Ph.D. Gastrointestinal Pathology Fellow

"Innovative Use of Artificial Neural Networks to Infer the Pharmacological Mechanisms of Drug Evoked Clinical Responses" Jonathan Wagg M.D., Ph.D., Oncology Disease Modeling Leader Clinical Pharmacology, Roche Innovation Center Basel Basel, Switzerland Tea at 12:15 PM Host: Dr. Dimitar Nikolov

"Transport Oncophysics and Post-Nanomedical Therapeutics" Mauro Ferrari, Ph.D. Ernest Cockrell, Jr Presidential Distinguished Chair President and CEO, Houston Methodist Research Institute Director, Institute for Academic Medicine at Houston Methodist Hospital Executive Vice President, Houston Methodist Hospital System

Host: Morgan Huse Tea at 1:15 PM "Novel pathways controlling T cell adhesion and migration" Name of Speaker: Victor Tybulewicz, Ph.D. Professor of Immune Cell Biology, Department of Medicine Senior Group Leader, Francis Crick Institute Speaker's Affiliation: Imperial College, London, UK

Deciphering a Logic for Epigenetic and Signaling Pathways Relevant to Cancer Host: Kayvan Keshari, Ph.D. Presenter: Benjamin P. Tu, Ph.D. Associate Professor, Department of Biochemistry University of Texas Southwestern Medical Center Dallas, TX Refreshments will be served at 4:00 PM

STUDENT: Kevin Patrick O’Rourke PROGRAM: Cell and Developmental Biology DISSERTATION: New Models of Colorectal Cancer to Facilitate Therapy Development for Metastatic Disease. Chairperson: Dr. Charles Sawyers Major Sponsor: Dr. Scott Lowe Minor Sponsor: Dr. David Solit Additional Member: Dr. Sohail Tavazoie (The Rockefeller University)

Drs. Blenis and Guzman invite you to the revamped Biomedical Science Reviews Seminar Series BSRSS is intended to provide the most up-to-date reviews of translational biomedical research by leaders in their fields and talented new investigators, for faculty, lab researchers, and clinical fellows. The revamped series will be held at the Belfer Research Building and at the Weill Medical College. 10/28: Selina Chen-Kiang, PhD Targeting CDK4/6 in Cancer: From Hypothesis to Therapy

Lee Grimes, Ph.D. Director, Cancer Pathology Program, Division of Experimental Hematology and Pathology Co-Leader, Program in Hematologic Malignancies Cincinnati Children's Hospital Medical Center Cancer and Blood Diseases Institute Professor, Department of Pediatrics University of Cincinnati Hosted by Drs. Olivier Elemento and Ari Melnick

55 Year-Old Male with Pancreatic Adenocarcinoma Himisha Beltran, M.D. - Assistant Professor of Medicine Erika Hissong, M.D. / Rohan Bareja, M.S. Pathology Resident / Bioinformatics Analyst NewYork-Presbyterian / Weill Cornell Medicine Refreshments will be served

Erika Hissong, M.D. Chief Pathology Resident "The Changing Face of Pathology: The Rise of Digital Pathology and the Social Pathologist" Luke Olson, M.D. Pathology Resident "Cell Phones and Cancer Risk: Is Your Addiction Killing You?" Monday, June 12, 2017 5p.m. John T. Ellis Pathology Library C-405

Dr. James Bussel, M.D. Professor of Pediatrics Professor of Pediatrics in Obstetrics and Gynecology and in Medicine Director, Platelet Research & Training Program Weill Cornell Medicine, New York, NY

"Regenerative Medicine and Congenital Malformations: Opportunities for Clinical Translation" Paolo De Coppi, M.D., Ph.D. NIHR Professor of Paediatric Surgery Nuffield Professor of Paediatric Surgery Head of Stem Cells & Regenerative Medicine Section Developmental Biology & Cancer Programme Consultant Paediatric Surgeon Great Ormond Street Hospital, London Host: Shahin Rafii, M.D. All are welcome!

Jim C. Hu, M.D., MPH Ronald Lynch Professor of Urologic Oncology; Director, Lefrak Center for Robotic Surgery; Professor of Urology; Attending Urologist, New-York Presbyterian Hospital "Controversies in the Treatment of Prostate Cancer and the Role of Device Registries"

"Selective Killing of KRAS and BRAF mutant tumors by Ascorbic Acid" Lewis Cantley, Ph.D. Meyer Director, Sandra and Edward Meyer Cancer Center Professor of Cancer Biology in Medicine Weill Cornell Medicine Manish Shah, M.D. Bartlett Family Associate Professor, Gastrointestinal Oncology Associate Professor of Medicine Weill Cornell Medicine

"A Novel Method of DNA Sequencing from Single Sperm Yields Insights into Recombination and Meiosis" Peter Donnelly, D.Phil. Professor of Statistical Science Head of the Department of Statistics Director, Wellcome Trust Centre for Human Genetics University of Oxford, Oxford, England Host: Scott Keeney Tea at 11:45 AM

This program will provide an opportunity for patients and caregivers to understand how bone marrow and stem cell transplant can play a vital role in the treatment of leukemia. Information on treatment options, questions to ask your care team, and local access to transplant treatment will be discussed. We encourage you to invite your caregiver and family members. Speakers Koen van Besien, M.D. Director, Bone Marrow and Stem Cell Transplant Program Weill Cornell Medicine/NewYork-Presbyterian Perry C. Cook, M.D. Attending Physician, Hematology/Oncology NewYork-Presbyterian Brooklyn Methodist Hospital Assistant Professor of Clinical Medicine, Weill Cornell Medicine Alan B. Astrow, M.D. Chief, Hematology/Oncology NewYork-Presbyterian Brooklyn Methodist Hospital Professor of Clinical Medicine, Weill Cornell Medicine Pre-registration for this free program is required.

Registration is not required and the meetings are free. June Topic: Reengaging After Prostate Surgery: Physical, Behavioral, and Environmental Issues Featured Speaker: Richard Sabel MA, MPH, OTR, GCFP Clinical Assistant Professor, Occupational Therapy, SUNY Downstate, Education Director, East West Rehab Institute Directions: Entrance North East corner of East 69th Street and York Ave. Take the “B” elevators next to the stairs to the 3rd floor and follow signs. For more information: Visit: www.ustoonewyork.org E-mail: info@ustoonewyork.org Call: (917) 830-HELP (4357)

Drs. Blenis and Guzman invite you to the revamped Biomedical Science Reviews Seminar Series BSRSS is intended to provide the most up-to-date reviews of translational biomedical research by leaders in their fields and talented new investigators, for faculty, lab researchers, and clinical fellows. The revamped series will be held at the Belfer Research Building and at the Weill Medical College. 10/28: Selina Chen-Kiang, PhD Targeting CDK4/6 in Cancer: From Hypothesis to Therapy

"Mutual Recognition in Illness: Finding a Relational Pulse" This presentation will illustrate a common journey toward healing, with two speakers exploring their search for a relational pulse in interpersonal encounters. The role of dreams, memories of trauma, dissociation, implicit and explicit communication during medical procedures, and complementary care will be discussed. At conclusion, participants will be more familiar with medical/oncology dyads, living with medical conditions, therapeutic ways to work with the shame of illness, and the transformative power of spontaneity. Featured Speakers Fran Conway Registered Oncology Nurse, Complementary Clinical Program Manager Urologic Health Center and Breast Cancer Program NewYork-Presbyterian Hospital, Weill Cornell Medical Center Certified Holistic Counselor Registered Yoga Therapist Fran Dillon Graduate, Columbia University School of Social Work Training Analyst TRISP (Training and Research Institute in Self Psychology) Co-Director Artist Study Group of Psychotherapy Service for People in the Arts William Alanson White Institute Psychotherapist, Psychoanalyst, Manhattan, Upper East Side Light refreshments will be served. RSVP: (646) 962-2072 or amm9052@med.cornell.edu

Want to know how to secure non-government funding for your research? Here’s a rare opportunity to meet with representatives from local foundations that collectively provide about $200M in research funding annually, including support for non-US investigators. Come find out how you can tap into this valuable resource! PARTICIPATING FOUNDATIONS Alzheimer’s Drug Discovery Foundation Cancer Research Institute Children’s Tumor Foundation Crohn’s & Colitis Foundation of America Damon Runyon Cancer Research Foundation JDRF National MS Society

Want to know how to secure non-government funding for your research? Here’s a rare opportunity to meet with representatives from local foundations that collectively provide about $200M in research funding annually, including support for non-US investigators. Come find out how you can tap into this valuable resource! PARTICIPATING FOUNDATIONS Alzheimer’s Drug Discovery Foundation Cancer Research Institute Children’s Tumor Foundation Crohn’s & Colitis Foundation of America Damon Runyon Cancer Research Foundation JDRF National MS Society Registration is strongly encouraged. For questions contact Teodora Staeva at tstaeva@med.cornell.edu. www.tri-cn.org

Jay P. Lopez Clinical Fellow, Department of Medicine Division of Hematology/Medical Oncology Weill Cornell Medicine, New York, NY

Satyajit Mayor, Ph.D. Professor, Cell Organization & Signaling National Centre for Biological Sciences, India

"Advanced Precision Oncology in Leukemia and Other Hematologic Malignancies" Dr. Duane Hassane Assistant Professor of Computational Biomedicine in Medicine Weill Cornell Medical College This seminar is open to all. Lunch will be provided.

Abby and Howard P. Milstein Chemistry Core Facility: Better Living Through Chemistry David Warren, Ph.D. Associate Research Professor Director, Milstein Chemistry Core Facility Weill Cornell Medicine Applications of the Modern Proteomic Toolbox Noah Dephoure, Ph.D. Assistant Professor of Biochemistry Sandra and Edward Meyer Cancer Center Weill Cornell Medicine

SPEAKER: Kanaka Rajan, Ph.D. Biophysics Theory Fellow Lewis-Sigler Institute for Integrative Genomics Princeton University TITLE: “Recurrent Network Models of Sequence Generation and Memory” Abstract: The sequential activation of neurons is a common feature of network activity during a variety of behaviors and has been proposed as a mechanism for cortical computation, including short term memory. Previous modeling approaches for sequences and memory networks have emphasized highly specialized architectures in which a principled mechanism is pre-wired into the connectivity of the network. In this work, we demonstrate that starting from random synaptic connectivity and allowing a small fraction of connections to undergo modification, a largely disordered recurrent network can produce sequences and short-term memory. We use this process, which we call Partial In-Network training (PINning), to model and match data from cellular-resolution imaging of neural activity in the mouse posterior parietal cortex (PPC) during a memory-guided two-alternative forced choice task in a virtual environment [Harvey, Coen & Tank, 2012]. In the model, as in the PPC data, individual neurons exhibit transient activations that are staggered relative to one another in time to form sequences spanning the duration of the task, and different sequences are activated on trials with different cues and choices. Analysis of the connectivity matrices of the minimally structured model networks revealed that the time-ordered neural activity is produced by the cooperation between recurrent synaptic interactions and external inputs, rather than feedforward connections, or the asymmetric connections of ring attractor models for sequences. In addition, our model showed that sequential activation across a population of neurons is an efficient mechanism for implementing short-term memory with comparable memory capabilities to previously proposed fixed point mechanisms. Together our results [Rajan, Harvey & Tank, 2016] develop a modeling framework based on generic, flexible, and minimally modified networks and suggest that neural activity sequences may emerge through learning from largely unstructured network architectures. HOST: Emre Aksay, Ph.D.

The Department of Radiation Oncology presents a special seminar featuring: Ilio Vitale, Ph.D. Regina Elena National Cancer Institute Università di Roma “Tor Vergata”, Rome, Italy

The Meyer Cancer Center Seminar Series presents: Benjamin Neel, M.D., Ph.D. Professor, Department of Medicine Director, Laura & Isaac Perlmutter Cancer Center New York University

"A Case Study: Drugging Undruggable Targets" David A. Scheinberg, M.D., Ph.D. Memorial Sloan Kettering Cancer Center (MSKCC) "TDI’s Resources for Discovering Breakthrough Drug Candidate(s) for Undruggable Targets" Michael Foley, Ph.D. Tri-Institutional Therapeutics Discovery Institute (Tri-I TDI) "Bridge Medicines’ Skill Set for Developing Drug Candidates into Approved Drug Products" William Polvino, M.D. Bridge Medicines

"Probing the Multivalent Readout of Chromatin Modification Patterns, One Molecule at a Time" Beat Fierz, Ph.D. Assistant Professor Laboratory of Biophysical Chemistry of Macromolecules (LCBM) Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland Host: Dr. Yael David Tea: 10:45 a.m.

"Proteomic Clues to Cell Organization" Martin Wuhr, Ph.D. Assistant Professor, Molecular Biology Princeton University Princeton, NJ Host: Philipp Niethammer Tea Time: 1:45pm

The Rockefeller University Special Seminar Series presents: Sebastian Amigorena, Ph.D. Director of Research Director of the Immunity and Cancer Unit Institut Curie, Paris

Drs. Blenis and Guzman invite you to the revamped Biomedical Science Reviews Seminar Series BSRSS is intended to provide the most up-to-date reviews of translational biomedical research by leaders in their fields and talented new investigators, for faculty, lab researchers, and clinical fellows. The revamped series will be held at the Belfer Research Building and at the Weill Medical College. 10/28: Selina Chen-Kiang, PhD Targeting CDK4/6 in Cancer: From Hypothesis to Therapy

"20 Month-Old Female with CNS Embryonal Tumor 4 Year-Old Male with an Infiltrating Glioma" David Pisapia, M.D. Assistant Professor of Pathology and Laboratory Medicine Weill Cornell Medicine / NYP

The Physicians' Education Resource (PER) First Annual International Oncology Pathology Congress is a one-day conference for the management of patients with cancer. Oncologists and pathologists will improve their knowledge of novel treatment approaches and reinforce their confidence in applying state-of-the-art treatment strategies. Co-Chairs Alain Borczuk, M.D. Professor of Pathology and Laboratory Medicine Vice Chairman, Anatomic Pathology Department of Pathology and Laboratory Medicine Weill Cornell Medicine New York, NY Balazs Halmos, M.D. Professor of Clinical Medicine Director, Thoracic Oncology Director, Clinical Cancer Genomics Albert Einstein College of Medicine/Montefiore Medical Center Bronx, NY

"Dissecting the Evolution of Immune Responses to Infection" Scott Mueller, Ph.D. Associate Professor Department of Microbiology and Immunology The University of Melbourne, Parkville, Australia Host: Joseph Sun Tea: 1:15 PM

"Precision Cancer Medicine via Mitochondria" Anthony Letai, M.D., Ph.D. Associate Professor, Department of Medical Oncology Harvard Medical School, Boston, MA Host: Dr. Alex Kentsis Tea: 3:45 p.m.